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for example, while the H3K27me3 modification deposited by the PRC2 complex can silence genes, its fidelity during cell division is limited [163, 223]

Berlin R, Berlin H, Brante G, Pilbrant (1978) Vitamin B12 body stores during oral and parenteral treatment of pernicious anaemia

while the JNK signaling pathway is associated with apoptosis and proinflammatory cytokines 84

doi: 10.1016/j.neuron.2014.01.037 78 YangTTWangSJ

Epigenetic heterogeneity within tumors and treatment-driven clonal evolution Epigenetic heterogeneity within tumors is a major driver of treatment failure [196], with plasticity far exceeding that of genomic mutations, making it a key force in adaptive evolution [6]

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