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Notably, supplementing NADPH and using a pharmacological inhibitor of aldose reductase an enzyme using NADPH oxidase for the formation of sorbitol in high-glucose conditions - successfully restored the sensitivity to LPS-induced NET formation in high glucose conditions, while reducing high glucose-induced cytosolic ROS production, neutrophil elastase secretion and spontaneous NET release (Table 4)

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L-theanine and cystine pretreatment (280 mg/kg for 5 days) could significantly enhance the weight loss and survival rate of rats after the irradiation, which may be connected with the inhibition of apoptosis and the enhancement of the proliferation of bone marrow cells (74)

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One way to build and improve upon this method is through the use of 3D bioprinting technologies to create anatomically precise hollow organs that incorporate biomimetic inks with patient-derived cells ( Figure 5 )