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It is reported that with aging, the level of succinate decreases, which can be restored by phytochemical supplementation[65,66]

Tuncel D, Tolun FI, Gokce M, Imrek S, Ekerbier H (2008) Oxidative stress in migraine with and without aura

6.2 Potential pathophysiological mechanisms of gut microbiota and metabolite SCFAs in cytokine abnormalities SCFAs (such as acetate, propionate, and butyrate) activate receptors like FFAR2/3 and Gpr109a and inhibit histone deacetylase (HDAC), collectively suppressing the activation of the NF-B signaling pathway, thereby downregulating the expression of pro-inflammatory cytokines (202204)

Toll-like receptor activation: from renal inflammation to fibrosis

Szakcs, G., Vradi, A., zvegy-Laczka, C

Pivotally, BC is a prototypical multifactorial disease influenced by a complex interplay of genetic, hormonal, reproductive, environmental, and lifestyle factors 8