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The differential diagnosis is broad, from diabetes to B12 deficiency to autoimmune conditions to malignancy, and treatment varies dramatically by cause

If the oxidized form starts to pile up, it suggests your body is under significant demand and may need additional support to keep up with its internal cleanup processes

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Clinically used iron chelators such as DFO and DFP, initially developed for the treatment of iron overload in -thalassemia and hemochromatosis, have been shown to mitigate tissue injury by inhibiting Fenton reaction-driven lipid peroxidation (409, 410)

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Furthermore, additional DNMT inhibitors are presented in the Table 2