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Ned Tijdschr Geneeskd

The role of interleukin-36 in health and disease states

doi: 10.3233/JAD-160926 132

Friese MA, Montalban X, Willcox N, Bell JI, Martin R, Fugger L

Taken together, these data validate the structural model of the two binding sites, and show that the long helix provides the most binding affinity, while binding to the F-pocket provides a substantial enhancement of binding