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3.2.1 Gut-Bacterial microbiome and inflammation The gut microbiome, comprised of billions of microorganisms, has a key role in maintaining gut homeostasis

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Future studies should employ cell-specific knockout mouse models and tunable hydrogel-based 3D culture systems (allowing precise manipulation of ECM stiffness and ligand density) to directly test whether specific ECM alterations are sufficient to drive reproductive cell senescence and to elucidate the downstream signaling pathways involved 141,191

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Purity and actual copper loading are not verifiable without a certificate of analysis and, ideally, independent elemental analysis