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Phase 2 trials have included striatal binding of dopamine transporter in the secondary outcome measures (NCT03100149, NCT03318523, Table 2), which would be of interest to correlate with the clinical outcome measures, and the biofluid-measured alterations to improve understanding of the drug action mechanism

PPT1 inhibition induced lysosomal lipid peroxidation (LLP), which led to lysosomal membrane permeabilization and cell death that could be reversed by the antioxidant N-acetylcysteine (NAC) but not by other lipid peroxidation antioxidants

Furthermore, the esterification activity of MYCBP2 modulates neurodevelopment and axon integrity (Mabbitt et al

Taking more does not always mean better results, so we must follow recommended amounts

Tamber SS, Bansal P, Sharma S, Singh RB, Sharma R (2023) Biomarkers of liver diseases

*Correspondence: Jisen Zhang, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Plant Development and EvoDevo, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers