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doi: 10.1002/dmrr.v34.3 267 WuDWuCZhongY

It includes: This format lets research labs evaluate each component under matched preparation conditions across independent mechanistic assays

Key gaps include limited human RCTs for mechanism validation, overlooked microbiota-nutrient bidirectional interactions, and lack of personalized strategies

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This makes it valuable for patients with documented deficiencies, malabsorption syndromes (e.g., Crohns disease, postbariatric surgery), or acute medical needs such as severe thiamine deficiency

This is due to more steps being required in manufacturing purified proteins compared to that of small molecule drugs ( Future directions Due to the imperfect therapeutic efficacy and the extremely high costs associated with current treatments, there is a pressing need for novel therapeutics