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GSK3-mediated phosphorylation can render substrates as targets for proteasomal destruction, thus inactivating various oncogenic proteins, such as -catenin and c-Myc, to suppress tumor development 11

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Adherence is the key problem!If 70% of the patient discontinue the treatment after 6-12 month and regain the weight very quickly, handling the adherence weakness is much more helpful to the patient's health than another 3% weight loss.Alma's smart capsule we can probably load GLP1 or Amylin on a once / twice weekly oral dose

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BM-MSCs transplantation could benefit mitochondrial and induce mitochondrial transfer to rescue protect renal TECs, by inhibiting apoptosis and improved morphology, of tubular basement membrane and brush border structure