glutathione peroxidase 1 pathway Frontiers Overview of the ferroptosis pathway.

N.SuomiA

Release of glucuronic acid (reducing sugar) by acid or b-glucuronidase

Key mitochondrial and antioxidant molecules such as Cytochrome c, UCH-L1, and thioredoxin domain-containing protein 12 were significantly downregulated

AlqradMAIEl-AgamyDSIbrahimSRMSirwiAAbdallahHMAbdel-SattarEet al

Methods: Medicare beneficiaries aged 65 with cirrhosis (2 diagnoses of cirrhosis or its complications

To address these limitations, future research should prioritize: (1) developing more physiologically relevant preclinical models (e.g., humanized liver chimeras, diet-induced murine models with metabolic comorbidities) to better recapitulate human NAFLD pathophysiology