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Here is an article that gets into this in more detail...and my colleague Yang Hu just published a full strategic briefing that dives into this topic which is available to subscribers (or available for purchase)

These results for Lr GUS and Rg GUS likely reflect their unique active site features, appearing to be electrostatically and sterically occluded from processing this small molecule glucuronide substrate

Geocarto Int 33(10):10361047 Zhou Q, Su J, Arnbjerg-Nielsen K, Ren Y, Luo JH, Ye ZJ, Feng JM (2021) A GIS-Based Hydrological Modeling Approach for Rapid Urban Flood Hazard Assessment

By systematically varying the acoustic properties of synthetic sounds that mimic the stereotyped calls of males and by measuring the responses of females, he found that female grey treefrogs prefer the calls that are the most energetically expensive for the males to produce

The honest answer is: we do not know

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