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Examples of new Hypoxia-inducible factor (HIF) activating agents were added in S2, Peptide Hormones, Growth Factors, Related Substances, and Mimetics

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To view a copy of this license, visit About this article Cite this article Draper, C.F., Duisters, K., Weger, B

Moreover, during zinc deficiency, enzymes such as glycosyltransferases and proteases are impaired, resulting in faulty receptor trafficking, extracellular matrix disintegration and hypoglycosylated proteins, defects that underlie congenital disorders of glycosylation 137

For example, APM Entities vary not only in composition but also in size, so an estimated change in scores that puts just one large APM Entity above or below a QP or Partial QP threshold can appear to be a major change to the entire Advanced APM