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Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity

AOD-9604 accelerates fat loss. The scientific gap There are no high-quality randomized trials demonstrating that semaglutide + AOD-9604 produces better outcomes than semaglutide alone, or that it improves lean mass retention, resting metabolic rate, or long-term weight maintenance

Acknowledgements The authors thank all lab members for fruitful discussion, the mass spectrometry platform for excellent technical assistance, Amer Mujezinovic for excellent assistance in all animal experiments, and Nancy Mutsaers for graphical assistance

D.WagnerR.HuntP.GertsensteinM.NagyA.et al (2010)