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These metabolites, although more water-soluble, are significantly less pharmacologically active and are rapidly cleared through biliary and renal excretion

Anticancer Res 21:931957 Alter-Koltunoff M, Ehrlich S, Dror N et al (2003) Nramp1-mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1, and Miz-1

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On the other hand, rupture of an unstable plaque can give rise to an acute catastrophic cardiovascular event

The impact of elevated water ammonia concentration on physiology, growth and feed intake of African catfish ( Clarias gariepinus )