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In the present study, PFOS time dependently increased IRE1 (an ER stress marker) expression, indicating ER stress induction, which could be eliminated by l-Carnitine through its antioxidative activity

The need for nucleotide substrates increases substantially during inflammation, injury and wound healing, and consistently, disease severity correlated with loss of hypoxanthine in the epithelium in a chemically induced murine model of colitis 123

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And injecting into tissue that is already inflamed from a recent injection

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