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The enrichment gene sets with a p -value 0.05 and a false discovery rate (FDR) 0.25 in the GSEA were considered to exhibit statistically significant differences

and (3) administration of fluids, electrolytes, and other supportive care, as needed

European Journal of Lipid Science and Technology 105(9):497501

However, pediatric pharmacokinetics are distinct from adults due to developmental variability in hepatic enzyme expression, renal clearance, and bloodbrain barrier permeability

It refers to the specific state the molecule must be in to perform its vital work