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Although UA transporters are found in many cells and organs, they are mostly concentrated in kidney and intestine, i.e., in the organs with a key role in UA excretion and regulation of UA concentration in the body

Patients blood was then drawn and DSBs were measured in lymphocytes

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However, it is currently not known if LSM can predict risk of clinical outcomes

Reads were aligned to the human GRCh38 reference genome (Ensembl) using STAR 96 , and transcript summarization was carried out using featureCounts with subread package 97,98 and the annotation (GTF) from Gencode version 33

Its levels decline after age 60, and lower levels are linked to faster cognitive decline, while higher levels are associated with reduced risks of heart disease and overall mortality, suggesting its importance for healthy aging and disease prevention