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Responders with lanifibranor (pooled) were for E1: 15, 44 and 57%, E2: 31, 35 and 53%, and E3: 15, 28 and 40% for ADP unchanged, moderate or high increase, respectively

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Another multitarget MOR-DOR agonist, SRI-22141, was tested in the clinically relevant models of HIV neuropathy and chemotherapy-induced peripheral neuropathy, in which it was found that while providing equal or enhanced efficacy versus morphine, the tolerance was significantly reduced, with almost non-dependence during the course of repeated administration [59]