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Biomarkers of oxidative damage including malondialdehyde, F2-isoprostane, protein carbonyls and advanced glycation end products (AGE) are reported to be elevated in either the plasma, erythrocytes or liver of streptozotocin (STZ)-induced diabetic rats [228231], as well as in the plasma or urine of diabetic patients [232234], giving further evidence of ROS contribution to the onset, progression and pathological consequence of diabetes

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Taken together, GA is a multifactorial disease involving metabolic abnormalities, crystal deposition, inflammatory amplification, and the interplay among multiple forms of programmed cell death (PCD), which underscores the need to establish appropriate animal models capable of recapitulating these interconnected pathological events

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Residents also enjoy secured bicycle storage lockers, a laundry facility, clubhouse, on-site manager, picnic area, and playground