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found that overexpression of PGC-1 in muscle cells reduced oxidative stress and inflammation, suggesting that promoting mitochondrial biogenesis can have anti-inflammatory effects (St-Pierre et al., 2006)

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However, given that CGRP can stimulate smooth muscle contraction in human airways [160], and has been implicated in mucus secretion in normal airways [142, 143], it is predicted that inhibition of CGRP might be of benefit in COPD

Alternative medicine review : a journal of clinical therapeutic, 12(1), 924

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*Correspondence: Yongye Huang, [email protected] This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers