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However, unlike glycolytic and lipogenic pathways, where specific metabolic enzymes such as hexokinase 2 and FAS are known to be deregulated by oncogene(s) or by inactivation of tumor suppressors 16,17 , there is limited evidence for cancer-associated abnormal expression or activity of the enzymes directly involved in the FAO pathway

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a growing body of evidence has indicated that U0126 exerts its antioxidative activity through the MAPK/ERK-independent pathway 37

doi: 10.1002/jcsm.12525 71

As shown in Supplementary Table 5 , all other liver-associated parameters (-GT, ALP, ALT, bilirubin) varied significantly over time, with an increase due to LPS administration and a subsequent decrease to baseline until the end of the experiment