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Low levels of ROS act as second messengers for activating inflammatory intracellular signaling, such as NF-B and MAP kinase pathways (30)

Zhang et al., 2023a)

ThakkarSAnklamEXuAUlberthFLiJLiBet al

Mol Cancer Res (2003) 1(10):70715

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Effects of 4-HNE on cartilage homeostasis and subchondral bone 4-HNE is one of the secondary metabolites of oxidation of PUFAs, particularly omega-6 fatty acids such as arachidonic acid and linoleic acid [75]