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These patches may appear as freckles or larger, irregularly bordered dark spots known as macules

In the Western Norway B Vitamin Intervention Trial (WENBIT), a randomized, double-blind, placebo-controlled trial in 87 subjects with suspected CAD, vitamin B 6 supplementation (40 mg/day of pyridoxine) for a median of 10 months had no effect on coronary stenosis progression, assessed by quantitative angiography (47)

Neuroinflammation, oxidative stress and their interplay in neuropathic pain: focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies

In addition, non-neuronal cells residing in both the central nervous system (CNS) and peripheral nervous system (PNS) called glial cells, and among them mainly astrocytes, microglia, and oligodendrocytes provide essential metabolic and functional support to neurons, contributing to their plasticity [238,239,240,241]

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Limitations and strengths of the study and future research A key limitation of this study is the relatively small sample size