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Effective therapeutic paradigms appear to converge on modulation of the mitochondrial function, purinergic signaling, and neuroinflammation, often supplemented by nutritional regulators such as vitamin D and retinoids

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discussion S47-8, DOI:10.1002/ana.10479, PMID 12666097

Indeed, exosomes isolated from plasma following exercise decreased infarct size and improved cardiac function following an experimental model of IR, although no differences in exosome number were found following exercise intervention (Hou et al., 2019)