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Similarly, L-carnitine has been demonstrated in experiments to protect mice from the development of NAFLD through antioxidant and lipid metabolism reprogramming, but the specific mechanism still needs to be clarified [70]

Mller et al

Efficacy of oral vitamin B12 treatment in children

Prospective randomized controlled trial of hindfoot and ankle fusions treated with rhPDGF-BB in combination with a -TCP-collagen matrix

Iron has also been reported to participate in the regulation of tricarboxylic acid cycle in macrophages, which further modulated the production of inflammatory cytokines (118)

These nontargeting sgRNA sequences for generating Control-KO cells (5-CGCAGTCATTCGATAGGAAT-3) (Shalem et al, 2014), UBQLN2 (5-CGCGGTGCCCGAGAACAGCT-3), and UBQLN1 (5-GACATTAGCAACGGAAGCCC-3) were inserted into the BsmbI sites of a lentiCRISPRv2-blast plasmid (Addgene, Watertown, MA, USA plasmid 83480) using standard techniques