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(2) the conversion of glucose to pyruvate through glycolysis, followed by its entry into the mitochondria via pyruvate dehydrogenase, leading to substantial ATP production and carbon dioxide release through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation

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The overall results indicate that hyperglycemic condition is detrimental to BBB physiology

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In the same way, certain histone modifications, like the repressive mark H3K27me3 and the activating mark H3K4me3, have been shown to interact with DNA methylation patterns in a dynamic way to control gene transcription