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Increased metal content in the TDP-43A315T transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

The urea cycle has a high energy cost, equivalent to the hydrolysis of 4 ATP to 4 ADP

Redox imbalance, FeRD in particular, results from virus-induced HMRD and represents a critical state both in the pathogenesis of SARSCoV2 infection and host inflammatory response 27,48,49

254 While strict glycemic control effectively reduces microvascular complications, 255,256 its impact on CVD risk is unclear and may increase adverse events in some populations