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About this article Cite this article Arunim, Dagar, M., Solanki, M

The fact that increased lactate levels have been found in several different compartments of the body in these diseases only sharpens the interest

523,535 AChE/GSK-3 inhibitors 48 536 and 49, 537 developed through a pharmacophore linkage strategy, exhibited promising results by significantly inhibiting tau hyperphosphorylation and ameliorating cognitive disorders in scopolamine-treated ICR mice

While these drugs show potential in reducing amyloid plaque burden, they come with risks such as amyloid-related imaging abnormalities with edema (ARIA-E), which can pose significant challenges to their widespread clinical use (Kurkinen, 2023