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Sterol feedback regulation is characteristic of all genes involved in cholesterol biosynthesis and homeostasis, whereas cAMP-dependent regulation is unique, suggesting that CYP51A1 may play a tissue-specific role distinct from cholesterol biosynthesis

PFOS was capable of activating PPAR, as shown by target gene induction ( Cyp4a10 )

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So at least in my case, and again, this is anecdata, it seemed to

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