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ED can occur for various reasons, such as tobacco use, medical conditions and even injuries that damage important nerves or arteries

Mouse Studies All mice were intraperitonially injected with 100L tamoxifen (Cayman Chemical, 13258) on alternating abdominal sides for 5 consecutive days

Most research focused on short-to-medium term use (days to weeks)

10.1186/s12887-017-0958-x 116

The condition of the upper airway is influenced by the interplay between the positive intraluminal pressure that keeps the airway open and the opposing surface tension that tends to close it (17)

Similarly, oral exposure to AgNPs (0, 1, 5, 10, 25, 50 mg/kg bw/day for 4 weeks) induced dose-dependent toxicity in mice, evidenced by body weight suppression and reduced intestinal dendritic cell numbers, confirming that both systemic and local immune effects scale with dose (Ren et al., 2023)