The hsa-miR-181a-5p reduces oxidation resistance by controlling SECISBP2 in osteoarthritis
Csar Lpez-Camarillo, Universidad Autnoma de la Ciudad de Mxico, Mexico Updates Copyright 2019 de la Cruz Lpez, Toledo Guzmn, Snchez and Garca Carranc
Acetaminophen in doses above 2g/day (saturates sulfation and glucuronidation, depletes glutathione catastrophically) R Alcohol (depletes glutathione, NAD+, SAM-e, and directly damages hepatocytes) R Charcoal-grilled meats (heterocyclic amines that undergo bioactivation via sulfation and acetylation, generating DNA-reactive intermediates) R Chronic NSAID use (competes for glucuronidation and amino acid conjugation pathways) Excess fructose (depletes ATP and drives uric acid production, impairing energy-dependent conjugation) R Glyphosate residues on non-organic produce (disrupts glycine metabolism and chelates manganese) R High-dose turmeric or quercetin without cycling (both inhibit SULT1A1 and can paradoxically impair sulfation at high sustained doses) R Processed foods with benzoate preservatives (benzoic acid consumes glycine through conjugation, depleting the glycine pool for other Phase II reactions) R Proton pump inhibitors chronically (reduce magnesium absorption, impair glucuronidation) R Testing These tests can help identify which conjugation pathways are impaired and what is contributing to the dysfunction
This approach revealed that reduced periplasmic glutathione levels indeed resulted in significantly lower PhoA activity, in line with the more reduced roGFP-iL redox state in gshA
Role of glutamine metabolism in host defense against Mycobacterium tuberculosis infection
The defect was specific to the IL-12IFN- axis
