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Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor

Precursor-directed immune-mediated anemia Dogs and cats with precursor-directed immune-mediated anemia (PIMA, also called non-regenerative immune-mediated anemia) usually present with severe normocytic normochromic anemia (Hcts, 20% cells with bound IgG) in low numbers of dogs (5/17, 29%) and a similar number of precursors were expressing phosphatidylserine (20-80% of cells)