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Similarly, a study in rats with ischemic stroke showed that intravenously administered IGF-1 crosses the bloodbrain barrier and exerts its neuroprotective effects through IGF-1 receptors in the brain 65

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When GH is released in timed pulses rather than maintained at steady-state levels, it produces meaningfully different metabolic effects including better fat oxidation and a more favourable interaction with insulin sensitivity than continuous elevation does

doi: 10.3892/or.2012.2099 217 Garcia-MolinaPSola-LeyvaALuque-NavarroPMLasoARios-MarcoPRiosAet al

but some of the worse skin I have seen is when I have seen people take advice from something they have seen on IG, and just gone and spent a load of money on expensive products willy-nilly, without any advice - or they use too much and it makes their skin worse