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In contrast, a lack of blood circulation (ischemia) to the brain (or any other region) limits the energy supply, which further elevates free radical concentrations and leads to neuron death ( 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH ) ( 2 Epidemiology of stroke On average, approximately 85% of strokes are ischemic and 15% are hemorrhagic

Sung et al.s investigation into liver Kupffer cells disclosed 298 lactylation sites in 181 proteins, predominantly localized in the nucleus (60%), cytoplasm (28%), mitochondria (4%), cell projections (3%), and chromosomes (3%) [61]

In the latter case, 1.5 mg pimonidazole (Hypoxyprobe) in 100 l PBS was intraperitoneally injected into each mouse, followed by sacrifice 30 min later

Shirbaghaee and Bolhassani, 2016)

doi: 10.1016/j.nano.2014.09.004 290 LibbyP