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Additionally, a loss of GPER leads to increased susceptibility to insulin resistance in high-fat diet-fed mice

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There is evidence that ER stress is induced in granulosa cells of women with PCOS and in PCOS mouse model, and that it plays a role in the interplay between inflammation and apoptosis

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However, its important to note that these are observational insights and anecdotal experiences rather than findings from large-scale, peer-reviewed clinical trials

These markers may provide context for treatment response monitoring