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The prodrome phase precedes the emetic phase and is reported in approximately 61-93% of adult patients.3,63,73 Symptoms can include nausea, abdominal pain, and multiple autonomic symptoms, such as diaphoresis, intolerance to cold and heat, sialorrhea, pallor, and lethargy

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Its primary mechanism, autophagy induction, is directly relevant to skin: autophagy declines with age in skin cells, and restoring it supports cellular renewal and barrier function

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