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1 Introduction Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten ingestion in genetically susceptible individuals, characterized by a variable combination of gluten-related symptoms, CD-specific antibodies, HLA-DQ2 or HLA-DQ8 haplotypes, and enteropathy ( Although the global prevalence is estimated at approximately 1% in the general population, marked geographic variability exists, with higher rates reported in Northern Europe, parts of the Middle East, and North Africa ( The clinical spectrum of CD has broadened substantially over recent decades

Preclinical and in vitro sources can show how researchers model redox systems, enzyme-linked reactions, and glutathione-dependent pathways [6] [9]

doi: 10.1021/jm0105070 13 DolmatovaE

(CA 92630, USA)

In the validation stage, an independent cohort (Cohort 2) comprising four age- and sex-matched groups (30 RBD-PD patients, 14 non-RBD-PD patients, 30 iRBD patients and 30 Ctrl subjects, all of whom underwent gold-standard video polysomnography (vPSG) assessment for the confirmation of RBD status) was included

Future research should explore combination strategies of this drug with other therapies to maximize its therapeutic value