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As a result, immune cells such as TAMs, tumor-associated neutrophils (TANs), tumor-infiltrating T lymphocytes (TILs) and MDSCs can modulate cancer cachexia via the following mechanisms: (1) they impact key target organs such as skeletal muscle, adipose tissue and even the nervous system, inducing a cascade of pathological effects within these tissues through signal transduction mechanisms

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120 120 17 mm) containing 75 ml solid strength Murashige-Skoog medium (pH 5.7) (Sigma-Aldrich, M5524 supplemented with 2% sucrose and 1% agar)

Am J Pathol 2008;173:2-13