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2 The antioxidant mechanisms of NAC The antioxidant mechanisms of NAC are typically attributed to three main aspects: supplementing GSH, directly scavenging ROS, and reducing the disulfide bonds (Figure 1A)

Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB

While the System Xc-is considered the main source of Cys (LOU et al., 2022), studies suggest that Cys can also be synthesized through the sulfur transfer pathway when the System Xc-is inhibited (SHIMADA and STOCKWELL, 2015)

Likewise, miR-130b can repress the expression of LDLR, and peroxisome proliferator-activated receptor gamma (PPARy).28 In addition to these antiviral effects, CH25H and 25-HC may block membrane web formation required for the successful HCV-replication through miR-185 action

Consequently, mitochondria are indispensable for the sustenance of neuronal life, and their robust activity and functional integrity are crucial for the preservation of neuronal structure and vitality

Neurodevelopmental problems at 18 months among children exposed to paracetamol in utero: a propensity score matched cohort study