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10.4103/jpn.JPN_130_19 4 BaoZ

10.1016/j.pupt.2010.01.002 45 RheeJ.LeeK.KimD.LeeY.JeonO.KwonH.et al (2007)

Febuxostat is not recommended for patients with significant ischaemic heart disease or congestive heart failure

In particular, the contribution of HDAC4 to the sumoylation for MEF2 finally leads to transcription inhibition [80] while HDAC4-mediated sumoylation of ZXDC activates the transcription activity [81]