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Graves Disease (Hyperthyroidism) When the thyroid is overactive, the body is in a state of high oxidative stress

USP9X is a deubiquitinase that forms a multiprotein structure with the pseudokinase tribbles homolog 3 to activate Notch signaling

10.1097/01.MIB.0000435849.17263.c5 112

It is worth noting that these off-target effects may also become significant resistance factors promoting tumor progression, as targeted drugs might activate these targets to protect tumor cells [11]

Entrapment efficiency (EE%) stability suggests effective retention of quercetin without significant leakage, with all evaluations indicating a sustained capacity for drug encapsulation and a robust, physically stable formulation