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Nuclear PKM2 regulates the Warburg effect

Cystine can be sequentially converted into GSH, which is indispensable in maintaining the intracellular redox balance as it can be utilized by GPX4 as a cofactor to alleviate lipid peroxidation (LPO) [32, 33] (Fig

& Ren, J

Blood 106:838a, 2005

While its been popular in other countries around the world, demand stateside has recently grown, prompting the Food and Drug Administration to issue an advisory on injectable skin lightening agents