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Second, as mentioned above, c-Met inhibitors which target the interaction between HGF and c-Met may lose efficacy owing to cell attachment (Wang et al., 2001), gene amplification of c-Met, DCP binding to c-Met (Suzuki et al., 2005), gene mutation in the c-Met activation loop (Okuma and Kondo, 2016) and crosstalk with other membrane receptors (Garcia-Vilas and Medina, 2018)

Their transcriptional activity is controlled by a series of coregulatory proteins and posttranslational modifications (PTMs)

Steps of production are similar to human related formulation and guidelines of good manufacturing practices (GMP) are followed to ensure safe, sterile and effective product

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If you have questions about your medications or experience side effects, you dont always need to visit a doctors office

This study was financially supported by the Engineering Research Center of Cross-innovation on Traditional Chinese Medicine of Shanxi Province (No