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In the 5 years before enrollment, he had a 15% BMI reduction (decrease from 34 kg/m 2 ) secondary to a glucagon-like peptide-1 (GLP1) receptor agonist (liraglutide 20152021 and dulaglutide 2021 onwards) for diabetes management but a rising M-spike that increased 4-fold (0.24 to 1.21g/dL) during that period

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Given the limitations of current single-target therapies, interest has grown in natural products as promising multi-target agents for modulating AD pathology (Zhang et al., 2024)

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