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Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation

Specifically, the occurrence of peptide and protein aggregation in biological systems can cause diseases and in pharmaceutical drug products induce adverse immunological responses 10,11,12

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This section outlines the specific regulatory networks of ferroptosis and cuproptosis in major gastrointestinal malignancies, aiming to identify disease-specific pathways and therapeutic targets

According to Morikawa et al., MDSCs express the metabotropic glutamate receptor 2/3 (mGluR2/3), and the immunosuppressive effect of MDSCs can be reduced by the mGluR2/3 antagonist LY341495 [85] (Fig