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2020) Car-OO may behave as a prooxidant by further reaction with unsaturated lipids Thus carotenoids behave under normal conditions as antioxidants, however, under a high partial pressure of oxygen (and high concentration) they may lose their antioxidant properties and behave as prooxidants

A similar study used frozen post-mortem samples of cerebellum and Brodmann area 22 (temporal cortex) [30]

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Physiologically, free radicals are formed as a side effect of reactions naturally occurring in the human body, such as cellular respiration or metabolic processes

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