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Implications for drug development The discovery of CD36 as a "universal carrier" suggests that medicinal chemists can rationally enhance CD36 binding to improve intracellular exposure

Acetaldehyde-modified proteins have also been detected in the plasma (Liu et al., 1990) and haemoglobin of alcoholics (Niemela & Israel, 1992)

Recent epidemiological data have documented that the prevalence of COPD among adults aged 40 years and older ranges from 9% to 10% ( In addition to its direct harms to individual health, COPD imposes a substantial economic burden on families, healthcare systems, and society, driven by high medical expenditures and lost productivity ( 2 Risk factors for COPD Tobacco smoking stands as the paramount risk factor precipitating COPD

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2021;53(8):e14139

doi: 10.1073/pnas.1005963107 29 FrankDNSt