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Macrophages as multifaceted orchestrators of tissue repair: bridging inflammation, regeneration, and therapeutic innovation

To delineate IPAs mechanism in ISC proliferation, we performed single-cell RNA sequencing (scRNA-seq) on colonic crypts from Veh- and IPA-treated mice at D3 post-DSS challenge (Fig

Zanichelli F, Capasso S, Di Bernardo G, Cipollaro M, Pagnotta E, Carten M, et al

[DOI] [PubMed] [Google Scholar] (281).Felgner PL

After entering the cell via the SLC1A5 transporter, glutamine (Gln) is converted into glutamate (Glu) under the catalysis of glutaminase (GLS), which is further oxidatively deaminated by glutamate dehydrogenase (GLUD1) to form -ketoglutarate (-KG) and enters the TCA cycle, with GLS2 being regulated by P53 [59]

13) before diversification of the winning clone by error-prone PCR for further evolution