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S3), which is the ancestral strain from which the R6 and R801 strains were derived

These changes may be driven by mutations in oncogenes and tumor suppressor genes, which reprogram cellular metabolism to systematically meet the multifaceted biological demands of tumor cells, such as rapid proliferation, apoptosis resistance, and adaptation to microenvironmental stress including hypoxia and nutrient deprivation [8, 9]

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