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In this setting, any perturbation that lowers intracellular GSH to an as yet unknown threshold could eventually induce cell death and, in all likelihood, ferroptosis, but also significantly increase expression and secretion of numerous T2-associated proteins

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However, cancer cells have developed various mechanisms for T cell depletion, which is an adverse factor in HCC, circumventing immune monitoring, such as promoting T cell fatigue blocking T cell penetration, and inducing immunosuppressive factors [86]

It has been found that chronic inflammation could increase the risk of cancer

However, this process takes time and can vary depending on a number of factors